High Pressure X-ray Science Laboratory


Research Interest

 Our lab studies biological and soft matter systems using high pressure and X-ray techniques.

 A novel high pressure technique, called high pressure cryocooling, has been developed for biophysical and X-ray science. The method was primarily developed for crystal cryoprotection in macromolecular crystallography. It was revealed that the underlying physics involves interesting phase behaviors of glassy water at low temperatures.

 Using the high pressure method, we will study the phase behaviors of glassy water, water-protein interactions, and protein functions and dynamics at cryogenic temperatures.


 Our research paper was selected for the cover image in the Journal of International Union of Crystallography (IUCrJ).

 Congratulations to Jin Kyun Kim and Prof. Chae Un Kim whose research image appear on the cover of the January 2018 edition of IUCrJ.

 The image indicates the ultrahigh-resolution (0.9 Å) crystal structure of 7.0 atm CO2 hCA II (human Carbonic Anhydrase II). A closer view of the active site (Zn, CO2 binding site and His64) is shown through the entrance conduit with a 2FoFc map (in blue) contoured at 2.5σ (for His64) and 5.0σ (others). The isolated electron density of the C atom of CO2 is clearly visible in this ultrahigh-resolution structure.

For more information, please check the paper below.

Paper Scientific Commentary

Post Doc. Research Position

We are looking for Post Doc. Research fellows in the field of Biophysics, X-ray Diffraction, TEM, or Laser Spectroscopy.

Those who majored in physics, chemistry and biology are all welcome.

Please email a curriculum vitae(CV)

including a list of publication to Prof. Chae Un Kim.

Email: cukim@unist.ac.kr

Student Research Position

We are looking for ambitious graduate and undergraduate students.

Highly motivated students are welcome.

Please Contact Prof. Chae Un Kim

우리 연구실에서는 대학원생과 학부 연구 참여생들을 모집합니다.

관심있는 학생은 언제든지 연락 바랍니다.

Email: cukim@unist.ac.kr